Department of Dermatology, Le Mans Hospital, 194 Avenue Rubillard, FR-72037 Le Mans Cedex, France.
Acta Derm Venereol. 2019 Dec 1;99(13):1237-1240. doi: 10.2340/00015555-3307.
Changes in the duration of efficacy of botulinum toxin A injections for primary axillary hyperhidrosis have not been studied in depth. The aim of this study was to assess such changes. In a retrospective cohort of 220 patients, seen over a 17-year period, duration of efficacy was recorded, including duration of efficacy of first and last injections. Of 220 patients, 117 fulfilled the study criteria (79 females and 38 males, age 17-79 years, mean age 38.3 years). Patients received 3-24 injections (mean 5.5). The duration of efficacy of the first injections was 3 weeks to 30 months (median 6 months), and the duration of efficacy of the final injections was 3 weeks to 66 months (median 8 months) (p < 0.001). An increase in duration of efficacy occurred in 62% of patients with repeated injections. Of the 20 patients with a follow up ≥10 years, the mean number of treatments was 8.25/patient; in 18 of these patients the duration of efficacy increased by > 50%. In conclusion, repeated botulinum toxin A injections lead to an increase in duration of efficacy without secondary decrease.
肉毒毒素 A 注射治疗原发性腋窝多汗症的疗效持续时间变化尚未深入研究。本研究旨在评估这些变化。在一项回顾性队列研究中，共纳入了 220 例患者，随访时间为 17 年，记录了疗效持续时间，包括首次和末次注射的疗效持续时间。在 220 例患者中，有 117 例符合研究标准（79 名女性和 38 名男性，年龄 17-79 岁，平均年龄 38.3 岁）。患者接受了 3-24 次注射（平均 5.5 次）。首次注射的疗效持续时间为 3 周到 30 个月（中位数为 6 个月），末次注射的疗效持续时间为 3 周到 66 个月（中位数为 8 个月）（p<0.001）。重复注射的患者中有 62%的疗效持续时间延长。在随访时间≥10 年的 20 例患者中，平均每位患者的治疗次数为 8.25 次；在这些患者中的 18 例中，疗效持续时间延长了>50%。总之，重复肉毒毒素 A 注射可增加疗效持续时间，而不会出现继发性下降。
