School of Medicine, Ningbo University, Ningbo, Zhejiang, China.
Gastroenterology Department, Ningbo No. 9 Hospital, Ningbo, Zhejiang, China.
DNA Cell Biol. 2019 Oct;38(10):1147-1154. doi: 10.1089/dna.2019.4922. Epub 2019 Aug 27.
is a tumor suppressor gene closely related to gastric cancer. This meta-analysis was designed to assess the quality in the previous studies and establish the value of methylation in the prediction and prognosis of gastric cancer. The eligible literatures with publication deadline of May 3, 2019 were collected from PubMed, EMBASE, CNKI, Wanfang, and CNVIP databases. The correlation between methylation level and gastric cancer was estimated by odds ratio and 95% confidence interval (OR and 95% CI) values. A total of eight articles were included in the study. A total of 517 gastric cancer tissue samples and 517 adjacent nontumor tissue samples were included. The results of the analysis showed that had a significantly higher level of methylation in gastric cancer (OR = 17.56, 95% CI = 7.11-43.35, -value = 0.009). Meanwhile, we tested whether there was association of methylation with tumor metastasis, and we also analyzed whether there was a gender difference in methylation. However, our results showed no statistical significance of the two aforementioned tests ( > 0.1). Our study suggested that methylation could predict the risk of gastric cancer. However, it might not be feasible for the prediction of tumor metastasis.
是一种与胃癌密切相关的肿瘤抑制基因。本荟萃分析旨在评估既往研究的质量，并确定甲基化在胃癌预测和预后中的价值。从 PubMed、EMBASE、CNKI、万方和 CNVIP 数据库中收集了截止到 2019 年 5 月 3 日的合格文献。通过比值比和 95%置信区间（OR 和 95%CI）值来估计甲基化水平与胃癌之间的相关性。共有 8 篇文章纳入研究。共有 517 例胃癌组织样本和 517 例相邻非肿瘤组织样本纳入分析。结果表明，胃癌中 的甲基化水平显著升高（OR=17.56，95%CI=7.11-43.35，-值=0.009）。同时，我们检验了 甲基化与肿瘤转移之间是否存在关联，还分析了 甲基化是否存在性别差异。然而，我们的结果显示上述两项检验均无统计学意义（>0.1）。我们的研究表明， 甲基化可预测胃癌的发病风险，但可能不适用于肿瘤转移的预测。
