Nygard Brian, Brickey Doug, Greenwood Jennifer
Rosalind Franklin University of Medicine and Science: A Joanna Briggs Institute Affiliated Group, Chicago, Illinois, USA.
JBI Database System Rev Implement Rep. 2019 Oct;17(10):2152-2158. doi: 10.11124/JBISRIR-D-18-00009.
The objective of this systematic review is to determine the efficacy of intravenous magnesium sulfate when used to attenuate hemodynamic fluctuations associated with the creation of pneumoperitoneum in adults undergoing laparoscopic surgery.
Laparoscopic surgery has gained popularity as a result of improved patient outcomes postoperatively, but pneumoperitoneum alters the patient's physiology and hemodynamic profile during the intraoperative period. Magnesium sulfate is a non-opioid agent known for its ability to blunt the physiologic sympathetic response associated with exposure to noxious stimuli. Magnesium sulfate may be efficacious in combating undesirable hemodynamic changes associated with pneumoperitoneum.
Studies that included participants 18 years or older undergoing any laparoscopic surgery using pneumoperitoneum with CO2 insufflation will be considered. Studies will be excluded if patients were being treated for pheochromocytoma. Studies can employ any intravenous dosing strategy of magnesium sulfate, administered at any point in the perioperative period for the purpose of blunting the sympathetic response to creation of a pneumoperitoneum.
A systematic search of MEDLINE, CINAHL, Cochrane Library, Google Scholar, Trip Database, MedNar, Grey Literature Report and ProQuest Dissertations and Theses will be conducted to identify both published and unpublished studies on the topic of interest. The search will be limited to studies written in English and performed on humans. Studies will be selected for review based on inclusion criteria and will be appraised by two reviewers using a standardized appraisal tool.
PROSPERO CRD42019139991.
本系统评价的目的是确定静脉注射硫酸镁在减轻接受腹腔镜手术的成年患者气腹形成相关血流动力学波动方面的疗效。
由于术后患者预后改善，腹腔镜手术越来越受欢迎，但气腹会在术中改变患者的生理和血流动力学特征。硫酸镁是一种非阿片类药物，以其抑制与暴露于有害刺激相关的生理性交感反应的能力而闻名。硫酸镁可能有效对抗与气腹相关的不良血流动力学变化。
将纳入包括18岁及以上接受任何使用二氧化碳气腹的腹腔镜手术参与者的研究。如果患者正在接受嗜铬细胞瘤治疗，则将排除该研究。研究可采用任何硫酸镁静脉给药策略，在围手术期的任何时间给药，以抑制对气腹形成的交感反应。
将对MEDLINE、CINAHL、Cochrane图书馆、谷歌学术、Trip数据库、MedNar、灰色文献报告以及ProQuest学位论文和专题论文进行系统检索，以识别关于感兴趣主题的已发表和未发表研究。检索将限于用英文撰写并在人类身上进行的研究。将根据纳入标准选择研究进行综述，并由两名评审员使用标准化评估工具进行评估。
PROSPERO CRD42019139991。
