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术中知晓并能回忆:一项基于描述性调查的队列研究。

Intraoperative Awareness With Recall: A Descriptive, Survey-Based, Cohort Study.

机构信息

From the Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri.

Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan.

出版信息

Anesth Analg. 2019 Nov;129(5):1291-1297. doi: 10.1213/ANE.0000000000004358.

Abstract

BACKGROUND

Unintended intraoperative awareness with recall (AWR) is a potential complication of general anesthesia. Patients typically report recollections of (1) hearing sounds or conversations, (2) being unable to breathe or move, (3), feeling pain, and/or (4) experiencing emotional distress. The purpose of the current study was to identify and further characterize AWR experiences identified through postoperative surveys of a large unselected adult surgical cohort.

METHODS

This is a substudy of a prospective registry study, which surveys patients on their health and well-being after surgery. Responses to 4 questions focusing on AWR were analyzed. Patients who reported AWR with pain, paralysis, and/or distress were contacted by telephone to obtain more information about their AWR experience. The interview results for patients who received general anesthesia were sent to 3 anesthesiologists, who adjudicated the reported AWR episodes.

RESULTS

Of 48,151 surveys sent, 17,875 patient responses were received. Of these respondents, 622 reported a specific memory from the period between going to sleep and waking up from perceived general anesthesia and 282 of these reported related pain, paralysis, and/or distress. An attempt was made to contact these 282 patients, and 149 participated in a telephone survey. Among the 149 participants, 87 endorsed their prior report of AWR. However, only 22 of these patients had received general anesthesia, while 51 received only sedation and 14 received regional anesthesia. Three anesthesiologists independently adjudicated the survey results of the 22 general anesthesia cases and assigned 6 as definite AWR, 8 as possible AWR, and 8 as not AWR episodes. Of the 65 patients who confirmed their report of AWR after regional or sedation anesthesia, 37 (31 with sedation and 6 with regional anesthesia) had not expected to be conscious during surgery.

CONCLUSIONS

The complication of AWR continues to occur during intended general anesthesia. Many reports of AWR episodes occur in patients receiving sedation or regional anesthesia and relate to incorrect expectations regarding anesthetic techniques and conscious experiences, representing a potential target for intervention.

摘要

背景

术中知晓伴回忆(AWR)是全身麻醉的潜在并发症。患者通常会报告回忆起(1)听到声音或对话,(2)无法呼吸或移动,(3)感到疼痛,和/或(4)经历情绪困扰。本研究的目的是通过对大量未选择的成年手术队列进行术后调查,确定并进一步描述 AWR 经历。

方法

这是一项前瞻性登记研究的子研究,该研究调查了患者手术后的健康和幸福感。对 4 个重点关注 AWR 的问题的回答进行了分析。报告 AWR 伴疼痛、麻痹和/或痛苦的患者通过电话联系,以获取更多关于其 AWR 经历的信息。将接受全身麻醉的患者的访谈结果发送给 3 位麻醉师,由他们判断报告的 AWR 发作。

结果

在发送的 48151 份调查中,收到了 17875 名患者的回复。在这些受访者中,有 622 人报告了从入睡到从全麻中醒来期间的特定记忆,其中 282 人报告了相关的疼痛、麻痹和/或痛苦。试图联系这 282 名患者,其中 149 人接受了电话调查。在 149 名参与者中,有 87 人认可他们之前报告的 AWR。然而,只有 22 名患者接受了全身麻醉,而 51 名患者仅接受镇静,14 名患者接受区域麻醉。3 位麻醉师独立判断了 22 例全身麻醉病例的调查结果,将 6 例判定为明确的 AWR,8 例判定为可能的 AWR,8 例判定为非 AWR 发作。在确认接受镇静或区域麻醉后报告 AWR 的 65 名患者中,有 37 名(31 名接受镇静,6 名接受区域麻醉)预计在手术期间不会有意识。

结论

AWR 并发症在全身麻醉期间仍会发生。许多 AWR 发作的报告发生在接受镇静或区域麻醉的患者中,与对麻醉技术和意识体验的错误预期有关,这代表了一个潜在的干预目标。

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