Synaptic Plasticity Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
Int J Mol Sci. 2019 Aug 26;20(17):4171. doi: 10.3390/ijms20174171.
Syntenin is an adaptor-like molecule that has two adjacent tandem postsynaptic density protein 95/Discs large protein/Zonula occludens 1 (PDZ) domains. The PDZ domains of syntenin recognize multiple peptide motifs with low to moderate affinity. Many reports have indicated interactions between syntenin and a plethora of proteins. Through interactions with various proteins, syntenin regulates the architecture of the cell membrane. As a result, increases in syntenin levels induce the metastasis of tumor cells, protrusion along the neurite in neuronal cells, and exosome biogenesis in various cell types. Here, we review the updated data that support various roles for syntenin in the regulation of neuronal synapses, tumor cell invasion, and exosome control.
衔接蛋白是一种衔接子样分子，具有两个相邻的串联后突触密度蛋白 95/盘状结构域大蛋白/闭合小带 1（PDZ）结构域。衔接蛋白的 PDZ 结构域识别具有低至中等亲和力的多种肽基序。许多报告表明衔接蛋白与大量蛋白质之间存在相互作用。通过与各种蛋白质相互作用，衔接蛋白调节细胞膜的结构。因此，衔接蛋白水平的增加会诱导肿瘤细胞的转移、神经元细胞中沿着突起的延伸以及各种细胞类型中的外体发生。在这里，我们综述了支持衔接蛋白在神经元突触调节、肿瘤细胞侵袭和外体控制中的各种作用的最新数据。
