唾液腺的生理学、病理学和再生。

University of Zurich, Institute of Oral Biology, Plattenstrasse 11, CH-8032 Zurich, Switzerland.

Cells. 2019 Aug 26;8(9):976. doi: 10.3390/cells8090976.

Salivary glands are essential structures in the oral cavity. A variety of diseases, such as cancer, autoimmune diseases, infections and physical traumas, can alter the functionality of these glands, greatly impacting the quality of life of patients. To date, no definitive therapeutic approach can compensate the impairment of salivary glands, and treatment are purely symptomatic. Understanding the cellular and molecular control of salivary glands function is, therefore, highly relevant for therapeutic purposes. In this review, we provide a starting platform for future studies in basic biology and clinical research, reporting classical ideas on salivary gland physiology and recently developed technology to guide regeneration, reconstruction and substitution of the functional organs.

唾液腺是口腔内的重要结构。多种疾病，如癌症、自身免疫性疾病、感染和物理创伤，会改变这些腺体的功能，极大地影响患者的生活质量。迄今为止，尚无明确的治疗方法可以弥补唾液腺的损伤，治疗方法纯属对症治疗。因此，了解唾液腺功能的细胞和分子控制对于治疗目的至关重要。在这篇综述中，我们为基础生物学和临床研究的未来研究提供了一个起点，报告了关于唾液腺生理学的经典观点和最近开发的指导功能性器官再生、重建和替代的技术。