Matrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.
Physiol Rev. 2022 Jul 1;102(3):1495-1552. doi: 10.1152/physrev.00015.2021. Epub 2022 Mar 28.
Salivary glands produce and secrete saliva, which is essential for maintaining oral health and overall health. Understanding both the unique structure and physiological function of salivary glands, as well as how they are affected by disease and injury, will direct the development of therapy to repair and regenerate them. Significant recent advances, particularly in the OMICS field, increase our understanding of how salivary glands develop at the cellular, molecular, and genetic levels: the signaling pathways involved, the dynamics of progenitor cell lineages in development, homeostasis, and regeneration, and the role of the extracellular matrix microenvironment. These provide a template for cell and gene therapies as well as bioengineering approaches to repair or regenerate salivary function.
唾液腺产生并分泌唾液，这对于维持口腔健康和整体健康至关重要。了解唾液腺的独特结构和生理功能，以及它们如何受到疾病和损伤的影响，将指导我们开发治疗方法来修复和再生它们。最近的重大进展，特别是在 OMICS 领域，增加了我们对唾液腺在细胞、分子和遗传水平上发育的理解：涉及的信号通路、祖细胞谱系在发育、动态平衡和再生中的动态，以及细胞外基质微环境的作用。这些为细胞和基因治疗以及修复或再生唾液功能的生物工程方法提供了模板。
