Mahesh P K B, Gunathunga M W, Jayasinghe S, Arnold S M, Senanayake S, Senanayake C, De Silva L S D, Kularatna S
Melbourne School of Population and Global Health, University of Melbourne, Australia.
Ceylon Med J. 2019 Jun 30;64(2):52-58. doi: 10.4038/cmj.v64i2.8891.
Stroke is a leading disease accounting for burden of chronic NCDs especially in lower and lower-middle income (LMI) settings. Quality of Life (QOL) is considered as an important facet of determination of success of patient management. EQ-5D-3L is a generic QOL tool. It provides an index score amalgamating responses for five descriptive questions and a visual analogue scale (VAS) value.
To assess the validity and reliability of EQ-5D-3L for stroke patients in Sri Lanka, which is a LMI setting.
A descriptive cross sectional study was done among 100 stroke survivors among whom 50 each were managed at an ambulatory setting and an in-ward setting. A second wave of data collection was done for reliability analysis among one half of participants. The validity of EQ-5D-3L was assesses with five a-priori hypotheses. Reliability was assessed with test-retest method and with internal consistency. Non parametric Mann Whitney U test and Spearman correlation coefficients were used in the analysis.
The EQ-5D index scores had significant positive correlation with SF-36 domain scores (p<0.001). The EQ-5D VAS scores had significant positive correlation with SF-36 domain scores (p<0.01). Index and VAS values of the EQ-5D were proved to be valid in known-group comparison (p<0.001). Participants reporting some kind of impairment for EQ-5D-3L dimensions had lower SF-36 domain scores. All the kappa values in the analysis of test-retest method were significant (p<0.001). For the VAS score, the Spearman correlation coefficient in test-reter analysis was 0.993 (p<0.001). Cronbach’s alpha value was 0.928.
and Recommendations EQ-5D-3L questionnaire demonstrates construct validity and a is a reliable toolin measuring QOL among stoke survivors in Sri Lanka.
中风是导致慢性非传染性疾病负担的主要疾病，在低收入和中低收入（LMI）地区尤为如此。生活质量（QOL）被视为判定患者管理成功与否的一个重要方面。EQ-5D-3L是一种通用的生活质量工具。它提供一个综合五个描述性问题的回答及一个视觉模拟量表（VAS）值的指数得分。
评估EQ-5D-3L在斯里兰卡（一个中低收入地区）中风患者中的有效性和可靠性。
对100名中风幸存者进行了一项描述性横断面研究，其中50名在门诊环境中接受治疗，另外50名在住院环境中接受治疗。对一半参与者进行了第二轮数据收集以进行可靠性分析。通过五个预先设定的假设评估EQ-5D-3L的有效性。采用重测法和内部一致性评估可靠性。分析中使用了非参数曼-惠特尼U检验和斯皮尔曼相关系数。
EQ-5D指数得分与SF-36领域得分呈显著正相关（p<0.001）。EQ-5D VAS得分与SF-36领域得分呈显著正相关（p<0.01）。EQ-5D的指数和VAS值在已知组比较中被证明是有效的（p<0.001）。报告EQ-5D-3L维度存在某种损伤的参与者的SF-36领域得分较低。重测法分析中的所有kappa值均具有显著性（p<0.001）。对于VAS得分，重测分析中的斯皮尔曼相关系数为0.993（p<0.001）。克朗巴赫α值为0.928。
EQ-5D-3L问卷显示出结构效度，是测量斯里兰卡中风幸存者生活质量的可靠工具。
