色氨酸代谢途径和蝶呤在临床实践中的哮喘患儿。
Tryptophan metabolic pathway and neopterin in asthmatic children in clinical practice.
机构信息
Pediatrics Clinic, Department of Pediatrics, Ospedale San Matteo, University of Pavia, Pavia, Italy.
Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
出版信息
Ital J Pediatr. 2019 Aug 28;45(1):114. doi: 10.1186/s13052-019-0699-6.
Tryptophan metabolic pathway is involved in pathogenic mechanisms of asthma. This study aimed to evaluate tryptophan metabolites and neopterin in a group of asthmatic children. Tryptophan metabolites and neopterin were measured in asthmatic children (121, 71 males, 50 females, mean age 11.6 + 3.2 years) and well-matched healthy controls (63, 32 males, 31 females, mean age 10.7 + 2.6 years). Tryptophan, kynurenine, and neopterin levels were significantly higher in asthmatic children than in healthy controls (p < 0.01; p < 0.01; p = 0.0015 respectively). Tryptophan metabolites and neopterin are increased in asthmatic children; these mediators underline the complex mechanisms involved in the immune response in asthma.
色氨酸代谢途径与哮喘的发病机制有关。本研究旨在评估一组哮喘儿童的色氨酸代谢物和新蝶呤。在哮喘儿童（121 例，男 71 例，女 50 例，平均年龄 11.6±3.2 岁）和匹配良好的健康对照组（63 例，男 32 例，女 31 例，平均年龄 10.7±2.6 岁）中测量了色氨酸代谢物和新蝶呤。与健康对照组相比，哮喘儿童的色氨酸、犬尿氨酸和新蝶呤水平显著升高（p<0.01；p<0.01；p=0.0015）。哮喘儿童的色氨酸代谢物和新蝶呤增加；这些介质强调了哮喘中免疫反应涉及的复杂机制。
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