Institute of Anatomy and Cell Biology, Justus-Liebig-University, Giessen, Germany; Member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center, Giessen and Marburg, Marburg, Germany; Member of the Center for Mind, Brain and Behavior (CMBB) of the Philipps-University Marburg and the Justus Liebig University Giessen at the Research Campus Central Hessen (FCMH), Marburg, Germany.
Institute of Anatomy and Cell Biology, Saarland University, Homburg/Saar, Germany.
J Allergy Clin Immunol. 2018 Nov;142(5):1415-1422. doi: 10.1016/j.jaci.2018.09.011.
Neuroimmune interaction has long been discussed in the pathogenesis of allergic airway diseases, such as allergic asthma. Mediators released during inflammation can alter the function of both sensory and parasympathetic neurons innervating the airways. Evidence has been provided that the inflammatory response can be altered by various mediators that are released by sensory and parasympathetic neurons and vice versa. Our aim is to demonstrate recent developments in the reciprocal neuroimmune interaction and to include, if available, data from in vivo and clinical studies.
神经免疫相互作用在过敏性气道疾病（如过敏性哮喘）的发病机制中很早就被讨论过。炎症期间释放的介质可以改变支配气道的感觉神经元和副交感神经元的功能。有证据表明，炎症反应可以被感觉神经元和副交感神经元释放的各种介质改变，反之亦然。我们的目的是展示最近在相互神经免疫相互作用方面的发展，并尽可能纳入体内和临床研究的数据。
