Wang Zhiguo, Wang Wei, Wu Guocheng
Department of Respiratory and Critical Care Medicine, The PLA Navy Anqing Hospital, Anqing, 246003, Anhui Province, China.
J Cardiothorac Surg. 2019 Aug 28;14(1):155. doi: 10.1186/s13019-019-0979-7.
This study aimed to study the clinical efficacy of argon plasma coagulation plus cryotherapy for central airway stenosis caused by lung cancer.
The clinical data of 177 patients with central airway stenosis caused by lung cancer received surgery from June, 2017 to July 2018 were retrospectively analyzed. According to different treatments, 43 patients received cryotherapy were included in the control group, while 134 patients received argon plasma coagulation plus cryotherapy were in the observation group. After propensity score matching, patients in the two groups were in a 1:1 ratio. The Karnofsky score, partial pressure of oxygen (PaO), arterial oxygen saturation (SaO), partial pressure of arterial carbon dioxide (PaCO) and adverse reactions in patients were analyzed one week before and after treatment. Besides, the survival rates of the two groups were compared.
After propensity score matching, the baseline data were not significantly different between the two groups. The post-treatment Karnofsky scores in the two groups were significantly higher than those of before treatment, and the post-treatment score of the observation group was higher than that of the control group (all P < 0.05). The post-treatment PaO and SaO in the observation group were both higher than those of the control group; while the PaCO in the observation group was significantly lower than that of the control group (all P < 0.05). In the observation group, the levels of PaO and SaO were significantly higher, and the level of PaCO was significantly lower after treatment than those of before treatment (all P < 0.05). The rates of completely effective and mild effective in the observation group were significantly higher than those in the control group (both P < 0.05). The incidences of bleeding, arrhythmia and fever in the observation group were significantly lower than those in the control group (all P < 0.05). The survival rate was significantly higher in the observation group (72.09%) than in the control group (51.16%).
Argon plasma coagulation combined with cryotherapy can significantly alleviate the central airway stenosis caused by lung cancer, reduce the incidence of adverse reactions, and improve prognosis in patients.
本研究旨在探讨氩等离子体凝固联合冷冻治疗肺癌所致中央气道狭窄的临床疗效。
回顾性分析2017年6月至2018年7月期间接受手术治疗的177例肺癌所致中央气道狭窄患者的临床资料。根据不同治疗方法，将43例接受冷冻治疗的患者纳入对照组，134例接受氩等离子体凝固联合冷冻治疗的患者纳入观察组。经倾向得分匹配后，两组患者按1:1比例进行配对。分析患者治疗前后1周的卡诺夫斯基评分、氧分压（PaO）、动脉血氧饱和度（SaO）、动脉血二氧化碳分压（PaCO）及不良反应情况。此外，比较两组患者的生存率。
倾向得分匹配后，两组患者的基线数据无显著差异。两组治疗后的卡诺夫斯基评分均显著高于治疗前，且观察组治疗后的评分高于对照组（均P < 0.05）。观察组治疗后的PaO和SaO均高于对照组；而观察组的PaCO显著低于对照组（均P < 0.05）。观察组治疗后PaO和SaO水平显著升高，PaCO水平显著降低，与治疗前相比差异均有统计学意义（均P < 0.05）。观察组的完全有效率和轻度有效率均显著高于对照组（均P < 0.05）。观察组出血、心律失常和发热的发生率均显著低于对照组（均P < 0.05）。观察组的生存率（72.09%）显著高于对照组（51.16%）。
氩等离子体凝固联合冷冻治疗可显著缓解肺癌所致中央气道狭窄，降低不良反应发生率，改善患者预后。
