College of Medicine, Chung-Ang University, 84 Heukseouk-ro, Donjak-gu, Seoul, 06974, South Korea.
Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul, 02841, South Korea.
Adv Rheumatol. 2019 Aug 27;59(1):40. doi: 10.1186/s42358-019-0084-6.
Rheumatoid arthritis (RA) is known to be associated with coronary artery diseases (CAD). Previous studies of the association between RA and CAD were reported mainly in non-Asian groups. We aimed to examine the prevalence of RA and the relationship between RA and CAD in South Korea.
We conducted a nationwide cross-sectional study by using the Korea National Health and Nutrition Examination Survey, which collected data for four years between 2008 and 2012. A total of 25,828 eligible participants were included. To balance the distribution of baseline characteristics, we used propensity score-matching. A multivariable logistic regression model was employed and we calculated the odds ratios (ORs) and 95% confidence intervals (CI) for the odds of the participants with RA on CAD prevalence.
The prevalence of RA in Korea from 2008 to 2012 was 0.6% and RA was predominant among elderly women. The prevalence of CAD in patients with RA was significantly higher than in general population. After propensity score-matching to balance the confounding factors, RA was significantly associated with CAD (OR 2.97, 95% CI 1.15-7.68, P = 0.02).
The prevalence of RA in South Korea was comparable to the worldwide data, and the presence of CAD in RA patients was more than two-fold.
类风湿性关节炎（RA）已知与冠状动脉疾病（CAD）有关。以前对 RA 与 CAD 之间关系的研究主要在非亚洲人群中报道。我们旨在检查韩国 RA 的患病率以及 RA 与 CAD 之间的关系。
我们通过韩国国家健康和营养检查调查进行了一项全国性的横断面研究，该调查在 2008 年至 2012 年期间收集了四年的数据。共纳入了 25828 名合格参与者。为了平衡基线特征的分布，我们使用倾向评分匹配。采用多变量逻辑回归模型，并计算了 RA 患者 CAD 患病率的优势比（OR）和 95%置信区间（CI）。
2008 年至 2012 年韩国 RA 的患病率为 0.6%，RA 主要发生在老年女性中。RA 患者的 CAD 患病率明显高于一般人群。在进行倾向评分匹配以平衡混杂因素后，RA 与 CAD 显著相关（OR 2.97，95%CI 1.15-7.68，P=0.02）。
韩国 RA 的患病率与全球数据相当，RA 患者的 CAD 患病率增加了两倍多。
