Department of Urology, Tulane University Health Sciences Center, New Orleans, LA, United States.
Department of Pharmacology, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Curr Stem Cell Res Ther. 2020;15(4):308-320. doi: 10.2174/1574888X14666190828142045.
According to the World Health Organization, more than 150 million people are diabetic, and this number will increase twofold by the year 2025. Diabetes-related complications affect all body organ systems, including the penis. Diabetes-induced Erectile Dysfunction (ED) is caused by neuropathy of the penile nerves and vasculopathy involving the smooth muscle and endothelium of the corpus cavernosum.
This study aims to present an overview of Stem Cell (SC) research in diabetic animal models of ED, focusing on the function, signaling, and niches that have a prominent role in the regeneration of cavernosal cells and penile tissues. We highlight common erectile pathologies caused by diabetes and review relevant preclinical trials. We also discuss paracrine mechanisms of various SC therapies involved in the repair of endothelial cells and cavernous nerves in these diabetic models.
A PubMed search was performed, with dates ranging from inception until Mar 31, 2019.
This review provides a comprehensive evaluation of the various strategies that have been investigated for improving SC delivery methods, through preclinical literature and published clinical trials regarding ED in men with diabetes. Various cell-type applications have benefited erectile function in diabetic models of ED.
This review examines the progress and remaining challenges in diabetes-related SC research regarding ED. Moving forward, it is only with a combined effort of basic biology and translational work that the potential of SC-based therapies in diabetes in ED can be realized.
根据世界卫生组织的数据，全球有超过 1.5 亿人患有糖尿病，到 2025 年，这一数字将翻一番。糖尿病相关并发症影响包括阴茎在内的所有身体器官系统。糖尿病引起的勃起功能障碍（ED）是由阴茎神经的神经病变和涉及海绵体平滑肌和内皮的血管病变引起的。
本研究旨在概述 ED 糖尿病动物模型中的干细胞（SC）研究，重点介绍在海绵体细胞和阴茎组织再生中起重要作用的功能、信号和龛位。我们强调了由糖尿病引起的常见勃起功能障碍，并回顾了相关的临床前试验。我们还讨论了各种 SC 治疗的旁分泌机制，这些机制涉及这些糖尿病模型中内皮细胞和海绵状神经的修复。
对 PubMed 进行了检索，检索日期范围为 1980 年 1 月 1 日至 2019 年 3 月 31 日。
本综述对改善 SC 输送方法的各种策略进行了全面评估，包括有关糖尿病男性 ED 的临床前文献和已发表的临床试验。各种细胞类型的应用都有益于 ED 糖尿病模型中的勃起功能。
本综述检查了与 ED 相关的糖尿病干细胞研究的进展和遗留挑战。只有通过基础生物学和转化工作的共同努力，才能实现基于干细胞的疗法在糖尿病 ED 中的潜力。
