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[消化道癌症的肠内营养]

[Enteral nutrition in digestive cancer].

作者信息

Rougier P, Nitenberg G

机构信息

Institut Gustave-Roussy, Villejuif.

出版信息

Ann Gastroenterol Hepatol (Paris). 1988 Nov;24(6):307-11.

PMID:3145699
Abstract

In view of the frequency and the importance of denutrition in digestive cancer patients, continuous enteral nutrition (EN) might be an useful adjuvant treatment should these patients be able to receive an efficient anti-tumoral course of treatment. EN is as effective as total parenteral nutrition in undernourished patients and probably decreases the extent and the frequency of post-operative complications. In contrast, when considered as a complement to radiation therapy or chemotherapy, EN does not enhance tolerance of treatment, response rate nor survival even though it improves the patient's nutritional status. These results must be considered with caution as most of the randomized trials conducted have only included small groups of patients. Further randomized trials are required in homogenous populations of digestive cancer patients in a state of undernutrition and who are eligible candidates for curative treatment. Basic research projects aiming at a specific form of nutritional support for cancer patients are badly needed.

摘要

鉴于营养不良在消化道癌症患者中出现的频率及其重要性,对于能够接受有效抗肿瘤治疗疗程的此类患者而言,持续肠内营养(EN)可能是一种有用的辅助治疗方法。在营养不良的患者中,肠内营养与全胃肠外营养效果相当,并且可能会降低术后并发症的发生率和严重程度。相比之下,当肠内营养被视为放疗或化疗的补充时,尽管它能改善患者的营养状况,但并不能提高治疗耐受性、缓解率或生存率。由于大多数已开展的随机试验仅纳入了少数患者群体,因此对这些结果必须谨慎看待。还需要在营养不良且有治愈性治疗资格的消化道癌症患者同质群体中开展进一步的随机试验。迫切需要针对癌症患者特定营养支持形式的基础研究项目。

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