Lan Ping, Herlt Anthony J, Willis Anthony C, Taylor Walter C, Mander Lewis N
Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory 2601, Australia.
ACS Omega. 2018 Feb 14;3(2):1912-1921. doi: 10.1021/acsomega.7b02065. eCollection 2018 Feb 28.
Following on our 60-year research on the chemical constituents of the rain forest trees and , we report the isolation of seven new alkaloids: GB14 (), GB22 (), GB25 (), GB21 (), GB23 (), GB24 (), and GB26 (). Their structures were elucidated by a combination of spectroscopic analyses and single-crystal X-ray crystallography, as well as structure degradation and interconversion. The newly isolated alkaloids are precursors or derivatives of the known family members from our early studies and could be intermediates in the biosynthesis of the alkaloids. Therefore, the present study has expanded the range of structures in this family of alkaloids and provided some missing links in the biosynthetic sequences.
在对雨林树木的化学成分进行了60年的研究之后，我们报告分离出了七种新生物碱：GB14（）、GB22（）、GB25（）、GB21（）、GB23（）、GB24（）和GB26（）。通过光谱分析、单晶X射线晶体学以及结构降解和相互转化相结合的方法阐明了它们的结构。新分离出的生物碱是我们早期研究中已知家族成员的前体或衍生物，可能是生物碱生物合成的中间体。因此，本研究扩展了该生物碱家族的结构范围，并提供了生物合成序列中一些缺失的环节。
