大豆成分混合复合物的溶解性特征评估

Evaluation of Solubility Characteristics of a Hybrid Complex of Components of Soy.

作者信息

Inoue Yutaka, Osada Mai, Murata Isamu, Kobata Kenji, Kanamoto Ikuo

机构信息

Laboratory of Drug Safety Management, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama 3500295, Japan.

Laboratory of Functional Food Science, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado-shi, Saitama, 3500295, Japan.

出版信息

ACS Omega. 2019 May 16;4(5):8632-8640. doi: 10.1021/acsomega.9b00733. eCollection 2019 May 31.

The purpose of this study was to evaluate the solubilities and physicochemical properties of solid dispersions of daidzein (DDZ) and genistein (GST) (the major isoflavones in soybeans) in γ-cyclodextrin (γCD). Dispersions were prepared in distilled water using a three-dimensional ball mill (3DGMw). Phase solubility diagrams confirmed that DDZ/γCD and GST/γCD formed A type inclusion complexes with a molar ratio of 1:1. A new peak due to inclusion complexes was observed in the results of powder X-ray diffraction (3DGMw(DDZ/γCD = 1:1) and 3DGMw(GST/γCD = 1:1)). Dissolution tests using distilled water found that solubilities of 3DGMw(DDZ/γCD = 1:1) and 3DGMw(GST/γCD = 1:1) were approximately 37- and 51-fold higher, respectively, than the solubilities of pure DDZ and GST. These observations are expected to expand the usefulness of cogrinding of DDZ or GST with γCD using a three-dimensional ball mill.

本研究的目的是评估大豆中的主要异黄酮黄豆苷元（DDZ）和染料木黄酮（GST）在γ-环糊精（γCD）中的固体分散体的溶解度和物理化学性质。使用三维球磨机（3DGMw）在蒸馏水中制备分散体。相溶解度图证实DDZ/γCD和GST/γCD形成摩尔比为1:1的A型包合物。在粉末X射线衍射结果中观察到由于包合物产生的新峰（3DGMw（DDZ/γCD = 1:1）和3DGMw（GST/γCD = 1:1））。使用蒸馏水进行的溶出度测试发现，3DGMw（DDZ/γCD = 1:1）和3DGMw（GST/γCD = 1:1）的溶解度分别比纯DDZ和GST的溶解度高约37倍和51倍。预计这些观察结果将扩大使用三维球磨机将DDZ或GST与γCD共研磨的用途。