[Dependence of changes in the luliberin level in the synaptosomal fraction of the olfactory bulbs and various areas of the hypothalamus on the level of sexual activity in male rats].

The paper is devoted to a study of the level of LH-RH in the synaptosomal fraction of the olfactory bulbs, preoptic area and mediobasal hypothalamus, and the blood level of HL in adult male rats with sexual activity after noradrenergic denervation of the preoptic area using 6-hydroxydopamine. A neurotoxic effect of 0.1% solution of ascorbic acid, preventing 6-hydroxydopamine disintegration, was noted. Both sexual activity and the level of LH-RH in synaptosomes of the preoptic area were lowered in male rats with noradrenergic denervation of the preoptic area. The maximum blood level of LH was observed during exposure to a recipient female rat. LH-RH concentration in the synaptosomal fraction of the olfactory bulbs being raised, that in the mediobasal hypothalamus lowered. The results were indicative of the involvement of HL-RH-synthesizing cerebral neurons with terminals in the olfactory bulbs, preoptic area and mediobasal hypothalamus in the regulation of sexual behavior, and the interaction of LH-RH-containing terminals with noradrenergic nerve endings at the level of the preoptic area.