El'tseva T V, Adamskaia E I, Peryshkova T A, Babichev V N
Probl Endokrinol (Mosk). 1992 Nov-Dec;38(6):46-50.
The present paper presents studies of the sexual behavior characteristics and the associated changes of LH releasing factor and of sex hormone receptor concentrations in hypothalamic regions involved in the regulation of sexual behavior activity and hypophyseal gonadotropic function (the anterior preoptic and mediobasal regions) of rats with streptozotocin-induced diabetes. The activities of both motivational and copulative components of sex behavior of such rats were found reduced. These changes were parallelled by LH-RH reduction in the median eminence and in the synaptosomal fraction of the anterior preoptic and mediobasal regions. An increased concentration of estradiol nuclear receptors was found in the anterior preoptic region, that may be responsible for the male feminization in diabetes and for weaker male sexual activity parameters. Blood levels of LH and FSH in experimental rats were virtually the same as in the reference animals, whereas prolactin and testosterone levels were reduced in the presence of elevated estradiol content. The majority of the detected hormonal shifts and sexual behavior characteristics normalized after compensatory insulin therapy. The authors come to a conclusion on the neuroendocrine disorders at the level of the CNS in animals with experimental diabetes during the formation of the motivational and copulative components of sexual behavior.
本文介绍了对链脲佐菌素诱导糖尿病大鼠性行为特征以及参与性行为活动调节和垂体促性腺功能的下丘脑区域（视前叶前部和中基底部）促黄体生成素释放因子和性激素受体浓度相关变化的研究。发现此类大鼠性行为的动机和交配成分的活动均降低。这些变化与视前叶前部和中基底部正中隆起及突触体部分中促性腺激素释放激素（LH-RH）的减少同时出现。在视前叶前部区域发现雌二醇核受体浓度增加，这可能是糖尿病中雄性雌性化以及雄性性行为参数较弱的原因。实验大鼠的促黄体生成素（LH）和促卵泡生成素（FSH）血液水平与对照动物基本相同，而在雌二醇含量升高的情况下，催乳素和睾酮水平降低。在进行补偿性胰岛素治疗后，大多数检测到的激素变化和性行为特征恢复正常。作者得出结论，在实验性糖尿病动物性行为的动机和交配成分形成过程中，中枢神经系统水平存在神经内分泌紊乱。
