Silverman J F, Blahove M, Collins J L, Norris H T
Department of Clinical Pathology and Diagnostic Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27834.
Am J Dermatopathol. 1988 Dec;10(6):536-40. doi: 10.1097/00000372-198812000-00011.
A unique case of a cutaneous malignant melanoma arising in a black man with a familial history of neurofibromatosis (von Recklinghausen's disease) is reported. Although neurofibromatosis is believed to be a disorder of neural crest origin that is associated with a number of different malignancies, a definite association of malignant melanoma with neurofibromatosis has not been reported. The presence of a malignant melanoma arising on the trunk of a black man suggests an association of cutaneous malignant melanoma and neurofibromatosis--a malignancy and genodermatosis, respectively--of ultimate neural crest origin.
报告了一例独特的皮肤恶性黑色素瘤病例，该病例发生在一名有神经纤维瘤病（冯·雷克林豪森病）家族史的黑人男性身上。尽管神经纤维瘤病被认为是一种起源于神经嵴的疾病，与多种不同的恶性肿瘤相关，但恶性黑色素瘤与神经纤维瘤病之间的确切关联尚未见报道。一名黑人男性躯干上出现恶性黑色素瘤，提示皮肤恶性黑色素瘤与神经纤维瘤病（分别为一种恶性肿瘤和遗传性皮肤病）之间存在关联，二者最终均起源于神经嵴。
