单激素人工胰腺在糖尿病治疗中的应用：临床疗效与尚存挑战
Single-Hormone Artificial Pancreas Use in Diabetes: Clinical Efficacy and Remaining Challenges.
作者信息
Taleb Nadine, Tagougui Sémah, Rabasa-Lhoret Rémi
机构信息
Clinical Research Institute, Montreal, Quebec, Canada.
Department of Biomedical Sciences, Université de Montréal, Montreal, Quebec, Canada.
出版信息
Diabetes Spectr. 2019 Aug;32(3):205-208. doi: 10.2337/ds18-0094.
Abstract
Artificial pancreas systems are rapidly developing and constitute the most promising technology for insulin-requiring diabetes management. Single-hormone systems (SH-AP) that deliver only insulin and have a hybrid design that necessitates patients' interventions around meals and exercise are the first to appear on the market. Trials with SH-AP have demonstrated improvement in time spent with blood glucose levels within target ranges, with a concomitant decrease in hypoglycemia. Longer and larger trials involving different patient populations are ongoing to further advance this important technology.
摘要
人工胰腺系统正在迅速发展，是治疗需要胰岛素的糖尿病最具前景的技术。仅输送胰岛素且采用混合设计、需要患者在进餐和运动时进行干预的单激素系统（SH-AP）是最早上市的。SH-AP的试验表明，血糖水平处于目标范围内的时间有所改善，同时低血糖发生率降低。涉及不同患者群体的更大规模、更长时间的试验正在进行中，以进一步推动这项重要技术的发展。
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