Sakib Sadman, Voigt Anna, Goldsmith Taylor, Dobrinski Ina
Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Canada.
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Canada.
Environ Epigenet. 2019 Jul 31;5(3):dvz011. doi: 10.1093/eep/dvz011. eCollection 2019 Jul.
Organoids are three dimensional structures consisting of multiple cell types that recapitulate the cellular architecture and functionality of native organs. Over the last decade, the advent of organoid research has opened up many avenues for basic and translational studies. Following suit of other disciplines, research groups working in the field of male reproductive biology have started establishing and characterizing testicular organoids. The three-dimensional architectural and functional similarities of organoids to their tissue of origin facilitate study of complex cell interactions, tissue development and establishment of representative, scalable models for drug and toxicity screening. In this review, we discuss the current state of testicular organoid research, their advantages over conventional monolayer culture and their potential applications in the field of reproductive biology and toxicology.
类器官是由多种细胞类型组成的三维结构，它概括了天然器官的细胞结构和功能。在过去十年中，类器官研究的出现为基础研究和转化研究开辟了许多途径。紧随其他学科之后，从事男性生殖生物学领域研究的团队已经开始建立和表征睾丸类器官。类器官与其起源组织在三维结构和功能上的相似性有助于研究复杂的细胞相互作用、组织发育，并有助于建立用于药物和毒性筛选的代表性、可扩展模型。在这篇综述中，我们讨论了睾丸类器官研究的现状、它们相对于传统单层培养的优势以及它们在生殖生物学和毒理学领域的潜在应用。
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