Joshi Mukesh, Naik Mayuresh P, Sarkar L
Department of Ophthalmology, V.M.M.C and Safdarjung Hospital, Ring Road, Ansari Nagar, New Delhi, India.
Department of Ophthalmology, H.I.M.S.R and H.A.H. Centenary Hopsital, Nears GK-2, Alaknanda, New Delhi, India.
J Family Med Prim Care. 2019 Jul;8(7):2429-2432. doi: 10.4103/jfmpc.jfmpc_314_19.
To evaluate the effect of intravitreal anti-VEGF on corneal endothelial cell count and central corneal thickness as well as to compare these in phakic and pseudophakic eyes.
The study was conducted in 102 eyes selected, as per selection criteria, over a time period of 18 months. At first patient visit, examination included: 1. Fundus examination. 2. Specular microscopy was done to look for endothelial cell count and Central corneal thickness. At second visit, Injection 0.5 mg/0.05 ml of ranibizumab was administered. Visits at day 1, day 7 and 1 month were done for Endothelial cell density and central corneal thickness was measured by specular microscope.
The mean CCT value in pseudophakic group was 502.08 ± 19.91, 501.9 ± 20.31, and 501.72 ± 21.55 on day 1, 7 and 30, respectively. The mean CCT value in phakic group was 506.53 ± 22.61, 505.96 ± 20.12, 505.92 ± 20.3 and 505.69 ± 21.47. The mean value of ECD in pseudophakic eyes on day 1, 7, and 30 were 2284.24 ± 299.86, 2281.39 ± 289.46 and 2284.06 ± 312.65 cells/mm, respectively. The mean value of ECD in phakic eyes on day 1, 7, and 30 were 2314.51 ± 212.08, 2313.92 ± 212.7 and 2313.63 ± 216.86 cells/mm, respectively.
There is no significant change in endothelial cell density, central corneal thickness, coefficient of variation and intraocular pressure before and after intravitreal injection over one month of follow-up. The results are similar between phakic and pseudophakic eyes.
评估玻璃体内注射抗血管内皮生长因子（VEGF）对角膜内皮细胞计数和中央角膜厚度的影响，并比较有晶状体眼和人工晶状体眼的这些指标。
按照入选标准，在18个月的时间段内选取102只眼进行研究。患者首次就诊时，检查包括：1. 眼底检查。2. 进行镜面显微镜检查以检测内皮细胞计数和中央角膜厚度。第二次就诊时，注射0.5毫克/0.05毫升雷珠单抗。在第1天、第7天和第1个月进行随访，通过镜面显微镜测量内皮细胞密度和中央角膜厚度。
人工晶状体眼组在第1天、第7天和第30天的平均中央角膜厚度（CCT）值分别为502.08±19.91、501.9±20.31和501.72±21.55。有晶状体眼组的平均CCT值分别为506.53±22.61、505.96±20.12、505.92±20.3和505.69±21.47。人工晶状体眼在第1天、第7天和第30天的内皮细胞密度（ECD）平均值分别为2284.24±299.86、2281.39±289.46和2284.06±312.65个细胞/平方毫米。有晶状体眼在第1天、第7天和第30天的ECD平均值分别为2314.51±212.08、2313.92±212.7和2313.63±216.86个细胞/平方毫米。
在随访的一个月内，玻璃体内注射前后内皮细胞密度、中央角膜厚度、变异系数和眼压均无显著变化。有晶状体眼和人工晶状体眼的结果相似。
