质子、钙和钾离子对心脏浦肯野纤维的相互作用。
The interactions of protons, calcium and potassium ions on cardiac Purkinje fibres.
作者信息
Brown R H, Cohen I, Noble D
出版信息
J Physiol. 1978 Sep;282:345-52. doi: 10.1113/jphysiol.1978.sp012467.
Abstract
- In sheep Purkinje fibres, acidosis shifts the steady-state current-voltage relation in an inward direction over a wide range of negative potentials. The reversal potential for iK2 is shifted in a positive direction. These changes are consistent with K+ accumulation in the extracellular spaces of the Purkinje fibre. 2. These effects of acidosis are completely prevented by increasing [K]0 from the normal range (2.7--5.4 mM) to 10.8 mM. 3. Increasing [Ca]0 from 2 to 6 mM also produces an inward shift in the steady-state current-voltage relation and a positive shift of the iK2 reversal potential. 4. In 10.8 mM-[K]0 these effects are absent even when [Ca]0 is increased to 20 mM. 5. One possible explanation is that K+ ions may protect the Na pump from inhibition by protons and Ca2+ ions. Alternative explanations are also discussed.
摘要
- 在绵羊浦肯野纤维中，酸中毒会使稳态电流 - 电压关系在很宽的负电位范围内向内移动。iK2 的反转电位向正方向移动。这些变化与浦肯野纤维细胞外空间中 K⁺ 的积累一致。2. 通过将 [K]₀ 从正常范围（2.7 - 5.4 mM）增加到 10.8 mM，酸中毒的这些影响可被完全阻止。3. 将 [Ca]₀ 从 2 mM 增加到 6 mM 也会使稳态电流 - 电压关系向内移动以及 iK2 反转电位向正方向移动。4. 在 10.8 mM - [K]₀ 时，即使将 [Ca]₀ 增加到 20 mM，这些影响也不存在。5. 一种可能的解释是，K⁺ 离子可能保护钠泵免受质子和 Ca²⁺ 离子的抑制。还讨论了其他解释。
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