Matsumoto Kenji, Takeda Satoshi, Hirokane Tsukasa, Yoshida Masahiro
Faculty of Pharmaceutical Sciences , Tokushima Bunri University , 180 Nishihama-Boji, Yamashiro-cho , Tokushima 770-8514 , Japan.
Org Lett. 2019 Sep 20;21(18):7279-7283. doi: 10.1021/acs.orglett.9b02527. Epub 2019 Aug 29.
The first catalytic oxidative aniline-aniline cross-coupling reaction using oxygen as the terminal oxidant is reported. Anilines possessing a pyrrolidino group can be preferentially oxidized under mild aerobic conditions and reacted with other anilines to afford a variety of nonsymmetrical 2-aminobiphenyls with high selectivities. A heterogeneous palladium catalyst is used for the dehydrogenative cross-coupling of anilines with structurally diverse arenes. This reaction does not require stoichiometric oxidants and is an economical and environmentally friendly method.
报道了首例以氧气作为终端氧化剂的催化氧化苯胺-苯胺交叉偶联反应。带有吡咯烷基的苯胺在温和的有氧条件下可被优先氧化，并与其他苯胺反应，以高选择性地得到多种不对称2-氨基联苯。一种多相钯催化剂用于苯胺与结构多样的芳烃的脱氢交叉偶联反应。该反应不需要化学计量的氧化剂，是一种经济且环境友好的方法。
