Ali Hatem, Kishore Bhuvan, Baharani Jyoti
Department of Renal Medicine, Heart of England Teaching Hospitals, Birmingham, UK.
Department of Hematology, Heart of England Teaching Hospitals, Birmingham, UK.
Saudi J Kidney Dis Transpl. 2019 Jul-Aug;30(4):825-831. doi: 10.4103/1319-2442.265458.
Paraprotein gap is sometimes used as a screening tool in some autoimmune diseases, cancers, and screening for latent infections. The increase in the paraprotein gap in these diseases was hypothesized to be the result of increased levels of immunoglobulins, raising the total serum protein without any changes in serum albumin. Our aim was to assess the overall survival using novel chemotherapy, bortezomib compared to traditional ones and to assess if paraprotein gap could be used as a predictor of survival. Finally, we aimed to assess factors that could predict renal response in this population.
副蛋白间隙有时在某些自身免疫性疾病、癌症以及潜伏感染筛查中用作筛查工具。这些疾病中副蛋白间隙的增加被推测是免疫球蛋白水平升高的结果，这会使血清总蛋白升高而血清白蛋白无任何变化。我们的目的是评估使用新型化疗药物硼替佐米与传统化疗药物相比的总生存率，并评估副蛋白间隙是否可作为生存的预测指标。最后，我们旨在评估可预测该人群肾脏反应的因素。
