Ferrari V, Zaniboni A, Simoncini E, Marpicati E, Montini E, Moretti R, Marini G
III Div. Medicina Generale, Servizio di Oncologia, Fondazione Beretta, Brescia, Italy.
Chemioterapia. 1988 Dec;7(6):414-9.
We treated 21 patients with advanced breast cancer with buserelin, aminoglutethimide and cortisone acetate in an attempt to obtain a complete estrogen blockade both in premenopausal and postmenopausal patients. Ten patients (47%) obtained an objective response without any relevant side-effects. Dealing with hormonal data, it must be outlined that serum testosterone levels decreased significantly in postmenopausal patients, suggesting a possible explanation for the activity of luteinizing hormone-releasing hormone analogue in this group of patients.
我们用布舍瑞林、氨鲁米特和醋酸可的松治疗了21例晚期乳腺癌患者，试图在绝经前和绝经后患者中实现完全的雌激素阻断。10例患者（47%）获得了客观缓解且无任何相关副作用。在处理激素数据时，必须指出，绝经后患者的血清睾酮水平显著下降，这为促黄体生成素释放激素类似物在该组患者中的活性提供了一种可能的解释。
