Singapore National Eye Centre, Singapore, Singapore.
Singapore Eye Research Institute, Singapore, Singapore.
Retina. 2020 Aug;40(8):1512-1519. doi: 10.1097/IAE.0000000000002638.
To compare the appearance and frequency of detection of common features in eyes with polypoidal choroidal vasculopathy using multicolor imaging (MC) or color fundus photography (CFP).
Thirty-eight eyes with indocyanine green angiography-proven polypoidal choroidal vasculopathy, imaged with both MC and CFP, were graded by three independent retinal specialists. The presence of five prespecified pathological features (blood, exudation, polypoidal lesions, pigment epithelial detachments, and atrophy) was graded on each modality independently. Multimodal imaging including optical coherence tomography, fluorescein, and indocyanine green angiography was used as the gold standard.
Overall, there was no statistically significant difference in the ability of MC imaging compared with CFP in detecting the pathological features. Polypoidal lesions appear as small, dark green, round lesions which have higher contrast on MC compared with a nodular orange appearance seen on CFP. Polypoidal lesions can be identified noninvasively using both MC and CFP in about half of the cases.
There are differences in the appearance of polypoidal choroidal vasculopathy-associated features on MC compared with CFP. Both modalities are comparable for the detection of pathological features in eyes with polypoidal choroidal vasculopathy. MC imaging may be considered as an alternative to CFP.
比较多波长成像（MC）或彩色眼底照相（CFP）检测息肉状脉络膜血管病变患者常见特征的外观和检出频率。
对 38 只经吲哚青绿血管造影证实为息肉状脉络膜血管病变的眼进行 MC 和 CFP 成像，并由 3 位独立的视网膜专家进行分级。在每种模式下，独立评估五种预设的病理特征（血液、渗出、息肉状病变、色素上皮脱离和萎缩）的存在情况。使用多模态成像，包括光学相干断层扫描、荧光素和吲哚青绿血管造影作为金标准。
总体而言，MC 成像在检测病理特征方面与 CFP 相比没有统计学上的显著差异。与 CFP 上所见的结节状橙色外观相比，MC 上的息肉状病变呈小而深绿色的圆形，对比度更高。MC 和 CFP 都可以在大约一半的病例中无创地识别息肉状病变。
MC 与 CFP 相比，息肉状脉络膜血管病变相关特征的外观存在差异。两种模式在检测息肉状脉络膜血管病变眼的病理特征方面具有可比性。MC 成像可以作为 CFP 的替代方法。
