Lie-A-Huen L, Kingma J H
Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.
Eur J Clin Pharmacol. 1988;35(1):89-91. doi: 10.1007/BF00555514.
The rectal absorption of flecainide from an aqueous solution, a fatty suppository and a polyethyleneglycol suppository was studied in one patient with supraventricular tachycardia (Wolff-Parkinson-White syndrome) refractory for oral anti-arrhythmic treatment. Rectal absorption was found to be fast (t1/2abs = 1 h) and complete when flecainide was administered as a solution (relative bioavailability 100%). Flecainide was poorly absorbed from a fatty suppository. The polyethyleneglycol suppository gave absorption with a relative bioavailability of 80% and t1/2 abs = 1.2 h.
在一名口服抗心律失常治疗无效的室上性心动过速（预激综合征）患者中，研究了从水溶液、脂肪栓和聚乙二醇栓中直肠吸收氟卡尼的情况。当氟卡尼以溶液形式给药时，发现直肠吸收迅速（吸收半衰期 = 1小时）且完全（相对生物利用度100%）。氟卡尼从脂肪栓中的吸收较差。聚乙二醇栓的吸收相对生物利用度为80%，吸收半衰期 = 1.2小时。
