Ingemarsson I, Arulkumaran S, Chua S
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Gynecol Obstet Invest. 1988;26(2):130-5. doi: 10.1159/000293684.
The effects of an intravenous bolus injection of D2343 (0.75 or 1 mg) or terbutaline (0.25 mg) on spontaneous term labor were studied. The uterine activity was recorded by a transducer-tipped intrauterine catheter and calculated electronically by an uterine activity integrator module built in a conventional fetal monitor. After drug administration the uterine activity was reduced to a similar extent with D2343 and terbutaline but the contractions were abolished for a longer time with terbutaline injection (mean of 9.3-9.8 min compared with 17.0 min). Maternal blood pressure was unaffected in both groups but the increase in pulse rate was slightly higher in the D2343 groups. D2343 seems to have an effect ratio between uterine inhibitory capacity and cardiovascular side effects similar to terbutaline.
研究了静脉推注D2343（0.75或1毫克）或特布他林（0.25毫克）对足月自然分娩的影响。子宫活动通过带有传感器的宫内导管记录，并由传统胎儿监护仪内置的子宫活动积分模块进行电子计算。给药后，D2343和特布他林使子宫活动降低的程度相似，但注射特布他林后宫缩消失的时间更长（平均9.3 - 9.8分钟，而特布他林为17.0分钟）。两组产妇血压均未受影响，但D2343组的心率升高略高。D2343在子宫抑制能力和心血管副作用之间的效应比似乎与特布他林相似。
