Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
IRCCS, Istituto Auxologico Italiano, Milano, Italy.
J Clin Hypertens (Greenwich). 2019 Oct;21(10):1594-1595. doi: 10.1111/jch.13682. Epub 2019 Aug 29.
From the physiopathological point of view obstructive sleep apnoea (OSA) should be regarded as the phenotype with the highest potential to disrupt the normal circadian blood pressure (BP rhythm). Despite these assumptions, it is surprising, however, to note that the data supporting a link between OSA and paradoxical increase in nighttime BP (ie, the so-called reverse dipping pattern) are still very limited and in some ways not entirely consistent. Available evidence on the association between OSA and reverse dipping (RD pattern), contrary to what is commonly thought, is still scanty. Given the potential negative synergistic effect of these two conditions, it is essential to have studies targeting this topic available soon.
从病理生理学的角度来看，阻塞性睡眠呼吸暂停（OSA）应该被视为最有可能破坏正常昼夜血压（BP）节律的表型。尽管有这些假设，但令人惊讶的是，支持 OSA 与夜间血压反常升高（即所谓的反杓型模式）之间存在关联的数据仍然非常有限，在某些方面并不完全一致。关于 OSA 与反杓型（RD 模式）之间的关联的现有证据，与人们普遍认为的相反，仍然很少。鉴于这两种情况的潜在协同负面效应，尽快开展针对这一课题的研究至关重要。
