Maher E R, Othman S, Frankel A H, Sweny P, Moorhead J F, Hilson A J
Department of Nephrology, Royal Free Hospital, Hampstead, London, UK.
Nephrol Dial Transplant. 1988;3(5):608-11. doi: 10.1093/oxfordjournals.ndt.a091714.
The value of captopril-enhanced 99mTc DTPA scintigraphy as a screening test for renovascular disease was prospectively studied in 44 hypertensive patients suspected to have renal-artery stenosis. Renal impairment (plasma creatinine greater than 130 mumol/l) was present in 29 patients. At angiography 13 patients had unilateral stenosis, two bilateral stenosis, and 29 patients had no renovascular disease. Captopril induced a fall in split renal function in the kidney ipsilateral to the stenosis in all patients with unilateral disease (mean 52 +/- 23% to 44 +/- 21% of total renal function; P less than 0.001). A positive captopril scintigram (defined as a fall of 5% or more in split renal function) had a sensitivity of 85% and a specificity of 72% in the detection of unilateral renal-artery stenosis. Captopril-enhanced 99mTc DTPA scintigraphy is a promising non-invasive screening test for the detection of renal-artery stenosis.
对44例疑似患有肾血管疾病的高血压患者，前瞻性研究了卡托普利增强的99mTc DTPA闪烁扫描术作为肾血管疾病筛查试验的价值。29例患者存在肾功能损害（血浆肌酐大于130μmol/L）。血管造影显示，13例患者有单侧狭窄，2例双侧狭窄，29例患者无肾血管疾病。所有单侧疾病患者中，卡托普利使狭窄同侧肾脏的分肾功能下降（从总肾功能的平均52±23%降至44±21%；P<0.001）。在检测单侧肾动脉狭窄时，阳性卡托普利闪烁扫描图（定义为分肾功能下降5%或更多）的敏感性为85%，特异性为72%。卡托普利增强的99mTc DTPA闪烁扫描术是一种很有前景的用于检测肾动脉狭窄的非侵入性筛查试验。
