Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.
Department of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
Sci Rep. 2019 Aug 29;9(1):12566. doi: 10.1038/s41598-019-49041-z.
Myopia is very prevalent worldwide, especially among Asian populations. Orthokeratology is a proven intervention to reduce myopia progression. The current study investigated association between baseline corneal biomechanics and orthokeratology responses, and changes of corneal biomechanics from long-term orthokeratology. We fitted 59 adult subjects having myopia between -4.00D to -5.00D with overnight orthokeratology. Corneal biomechanics was measured through dynamic bidirectional corneal applanation (in terms of corneal hysteresis, CH and corneal resistance factor, CRF) and corneal indentation (in terms of corneal stiffness, S and tangent modulus, E). Subjects with poor orthokeratology responses had lower E (mean 0.474 MPa) than subjects with good orthokeratology responses (mean 0.536 MPa). Successful orthokeratology for 6 months resulted in reducing CH (reduced by 5.8%) and CRF (reduced by 8.7%). Corneal stiffness was stable, but E showed an increasing trend. Among subjects with successful orthokeratology, a higher baseline S resulted in greater myopia reduction (Pearson correlation coefficient, r = 0.381, p = 0.02).
近视在全球范围内非常普遍，尤其是在亚洲人群中。角膜塑形术是一种已被证实可减少近视进展的干预措施。本研究调查了基线角膜生物力学与角膜塑形术反应之间的关系，以及长期角膜塑形术对角膜生物力学的影响。我们对 59 名近视在-4.00D 至-5.00D 之间的成年人进行了一夜之间的角膜塑形术。通过动态双向角膜压平术（以角膜滞后、CH 和角膜阻力因子、CRF 表示）和角膜压痕（以角膜硬度、S 和切线模量、E 表示）测量角膜生物力学。角膜塑形术反应不佳的患者的 E 值（平均 0.474 MPa）低于角膜塑形术反应良好的患者（平均 0.536 MPa）。6 个月成功的角膜塑形术导致 CH（降低 5.8%）和 CRF（降低 8.7%）降低。角膜硬度保持稳定，但 E 值呈上升趋势。在成功进行角膜塑形术的患者中，较高的基线 S 导致近视减少更多（Pearson 相关系数，r=0.381，p=0.02）。
