抗病毒 T 细胞治疗的研发管线：临床应用和正在开发中的药物。
The pipeline of antiviral T-cell therapy: what's in the clinic and undergoing development.
机构信息
Center for Cancer and Immunology Research, Children's National Medical Center, Washington, District of Columbia.
Division of Allergy & Immunology, Center for Cancer and Blood Disorders, Washington, District of Columbia.
出版信息
Transfusion. 2020 Jan;60(1):7-10. doi: 10.1111/trf.15501. Epub 2019 Aug 30.
Abstract
Virus-specific T cells allow targeting of multiple pathogens in patients after hematopoietic stem cell transplantation and have demonstrated potential efficacy for cytomegalovirus, Epstein-Barr Virus, and adenovirus. Novel targets may include BK virus, JC virus, varicella zoster virus, human herpesvirus 6, Aspergillus, human parainfluenza virus-3, herpes simplex virus Type I, Zika virus, and mycobacteria. Generation of patient-specific products and third-party products may expand feasibility of therapy.
摘要
病毒特异性 T 细胞允许在造血干细胞移植后的患者中靶向多种病原体，并且已经证明对巨细胞病毒、EB 病毒和腺病毒具有潜在疗效。新的靶点可能包括 BK 病毒、JC 病毒、水痘带状疱疹病毒、人类疱疹病毒 6、曲霉属、人副流感病毒 3、单纯疱疹病毒 1 型、寨卡病毒和分枝杆菌。患者特异性产品和第三方产品的生成可能会扩大治疗的可行性。
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