铁催化甲基杂芳烃与伯醇的偶联反应：直接合成β-选择性烯烃
Iron-Catalyzed Coupling of Methyl -Heteroarenes with Primary Alcohols: Direct Access to -Selective Olefins.
作者信息
Das Jagadish, Vellakkaran Mari, Sk Motahar, Banerjee Debasis
机构信息
Department of Chemistry, Laboratory of Catalysis and Organic Synthesis , Indian Institute of Technology Roorkee , Roorkee 247667 , Uttarakhand , India.
出版信息
Org Lett. 2019 Sep 20;21(18):7514-7518. doi: 10.1021/acs.orglett.9b02793. Epub 2019 Aug 30.
An efficient Fe-catalyzed system is reported for direct α-olefination of methyl-substituted -heteroarenes with primary alcohols. The catalytic dehydrogenative coupling enables a series of functionalized -olefinated -heteroaromatics with excellent selectivity (>99%). Initial mechanistic studies including deuterium-labeling experiments provide evidence for the participation of the benzylic C-H/D bond of alcohols.
据报道，一种高效的铁催化体系可用于甲基取代的杂芳烃与伯醇的直接α-烯烃化反应。这种催化脱氢偶联反应能够生成一系列具有优异选择性（>99%）的官能化α-烯烃化杂芳烃。包括氘标记实验在内的初步机理研究为醇的苄基C-H/D键参与反应提供了证据。
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