Division of Allergy, Mayo Clinic, Rochester, Minn.
J Allergy Clin Immunol Pract. 2020 Feb;8(2):498-506. doi: 10.1016/j.jaip.2019.08.022. Epub 2019 Aug 27.
The current consensus diagnostic criteria for mast cell activation syndrome(s) (MCAS[s]) were first established in 2012 and updated in 2019. This diagnosis has been attached to multiple medical conditions not intended as part of the diagnosis. In this article, the diagnostic criteria are reviewed and other diseases in the differential diagnosis outlined. The goal of this review is to provide a tool for evaluation of patients with conditions that can mimic MCAS. Furthermore, the potential role for hereditary alpha-tryptasemia in this group of disorders is discussed.
目前，肥大细胞活化综合征（MCAS）的共识诊断标准于 2012 年首次建立，并于 2019 年更新。该诊断已应用于多种非诊断性疾病。本文回顾了诊断标准，并概述了鉴别诊断中的其他疾病。本文的目的是为评估可能类似于 MCAS 的病症的患者提供一种工具。此外，还讨论了遗传性α-胰蛋白酶血症在这组疾病中的潜在作用。
