Sadeghi Mahdi, Aboudzadeh Rovais Mohammad Reza, Zandi Nadia, Moradi Maedeh, Yousefi Kamran
Medical Physics Department, School of Medicine, Iran University of Medical Science, P.O. Box: 14155-6183, Tehran, Iran.
Radiation Application Research School, Nuclear Science and Technology Research Institute, P.O. Box 14395-836, Tehran, Iran.
Appl Radiat Isot. 2019 Dec;154:108877. doi: 10.1016/j.apradiso.2019.108877. Epub 2019 Aug 22.
Gold-199 is a promising theranostic radionuclide for targeted radioimmunotherapy as well as for scintigraphy and dosimetry. Au can be produced in two methods in the direct and indirect routes of the reactor production via Au(n,γ)Au(n,γ)Au as the direct or Pt(n,γ)Pt→Au as the indirect method. This investigation described the development of a method for the reactor production of no-carrier-added (NCA) Au through neutron activation of natural Pt in Tehran Research Reactor (TRR) at a thermal neutron flux of 3.5 × 10 n cm s. Also, in this paper, the activity of Au has been estimated using the MCNPX code. In this case, first, the reactor core is simulated. Then the calculated results are compared with the corresponding experimental values. Moreover, two different chemical separation methods are investigated experimentally in details.
金-199是一种很有前景的治疗诊断放射性核素，可用于靶向放射免疫治疗以及闪烁扫描和剂量测定。金可以通过反应堆生产的直接和间接途径中的两种方法来制备，直接途径是通过Au(n,γ)Au(n,γ)Au，间接途径是通过Pt(n,γ)Pt→Au。本研究描述了一种在德黑兰研究堆（TRR）中，利用热中子通量为3.5×10 n cm²s，通过天然铂的中子活化来生产无载体添加（NCA）金的反应堆生产方法。此外，本文还使用MCNPX代码估算了金的活度。在这种情况下，首先对反应堆堆芯进行模拟。然后将计算结果与相应的实验值进行比较。此外，还对两种不同的化学分离方法进行了详细的实验研究。
