一种新型放射性标记的接枝聚合物：利用白化Wistar大鼠研究其作为放射性药物的潜力。
A novel radiolabeled graft polymer: Investigation of the radiopharmaceutical potential using Albino Wistar rats.
作者信息
Avcıbaşı Uğur, Ateş Buket, Ünak Perihan, Gümüşer Fikriye Gül, Gülcemal Süleyman, Ol Kevser Kusat, Akgöl Sinan, Tekin Volkan
机构信息
Department of Chemistry, Manisa Celal Bayar University, Faculty of Art and Science, 45140, Manisa, Turkey.
Department of Chemistry, Manisa Celal Bayar University, Faculty of Art and Science, 45140, Manisa, Turkey.
出版信息
Appl Radiat Isot. 2019 Dec;154:108872. doi: 10.1016/j.apradiso.2019.108872. Epub 2019 Aug 22.
FeO magnetic graft-Lys-poly(HEMA) was synthesized, labeled with Tc for the first time and its radiopharmaceutical potential was investigated using animal models in this study. Quality control procedures were carried out using thin layer radiochromatography. The labeling yield of radiolabeled polymer was found to be about 100%. Then, stability and lipophilicity were determined. The lipophilicity of Tc labeled FeO graft-Lys-poly(HEMA) was found to be 3.77. The serum stability experiments demonstrated that approximately 100% of radiolabeled polymer existed as an intact complex in the rat serum within 240 min. Biodistribution of radiolabeled magnetic graft-Lys-poly(HEMA) was performed on female Albino Wistar rats by scintigraphy and biodistribution studies. High uptake was seen in the stomach, the pancreas, brain, ovarian, intestines and the breast.
合成了FeO磁性接枝-Lys-聚（甲基丙烯酸羟乙酯），首次用锝进行标记，并在本研究中使用动物模型研究了其作为放射性药物的潜力。采用薄层层析法进行质量控制程序。发现放射性标记聚合物的标记产率约为100%。然后，测定了稳定性和亲脂性。发现锝标记的FeO接枝-Lys-聚（甲基丙烯酸羟乙酯）的亲脂性为3.77。血清稳定性实验表明，在240分钟内，约100%的放射性标记聚合物在大鼠血清中以完整复合物的形式存在。通过闪烁扫描和生物分布研究，对雌性白化Wistar大鼠进行了放射性标记磁性接枝-Lys-聚（甲基丙烯酸羟乙酯）的生物分布研究。在胃、胰腺、脑、卵巢、肠道和乳腺中观察到高摄取。
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