Graduate School of Medicine, Korea University College of Medicine, Seoul 02841, Korea.
Department of Oncology, Korea University Guro Hospital, Korea University College of Medicine, Seoul 08308, Korea.
Nutrients. 2019 Aug 29;11(9):2026. doi: 10.3390/nu11092026.
Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, the mechanism of KRG-induced apoptosis is unknown in colorectal cancer (CRC). In our study, we examined whether KRG induces apoptosis in CRC cells.
In the cell viability assay, the concentration of the appropriate KRG extracts was fixed at 2.5 mg/mL in numerous CRC cells. This fixed concentration was in other experiments, and it was confirmed that the KRG extracts induce apoptosis in CRC cells.
We found that KRG induced Noxa activation and apoptosis and increased endoplasmic reticulum stress via reactive oxygen species production. This indicated that KRG efficiently enhanced cell death in CRC cells.
Our results show that KRG can be used as a possible anticancer drug for patients with CRC.
虽然韩国红参（KRG）在各种癌症中的抗癌活性已为人所知，但 KRG 诱导结直肠癌（CRC）细胞凋亡的机制尚不清楚。在我们的研究中，我们研究了 KRG 是否会诱导 CRC 细胞凋亡。
在细胞活力测定中，将适当的 KRG 提取物的浓度固定在许多 CRC 细胞中的 2.5mg/mL。在其他实验中，证实了 KRG 提取物会诱导 CRC 细胞凋亡。
我们发现 KRG 通过产生活性氧诱导 Noxa 激活和细胞凋亡，并增加内质网应激。这表明 KRG 能有效地增强 CRC 细胞的死亡。
我们的结果表明，KRG 可作为 CRC 患者的一种潜在抗癌药物。
