Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Departments of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Pharm Des. 2019;25(29):3165-3174. doi: 10.2174/1381612825666190830153056.
Atherosclerosis is a chronic inflammatory disease and a leading cause of coronary artery disease, peripheral vascular disease and stroke. Lipid-laden macrophages are derived from circulating monocytes and form fatty streaks as the first step of atherogenesis.
An electronic search in major databases was performed to review new therapeutic opportunities for influencing the inflammatory component of atherosclerosis based on monocytes/macrophages targeting.
In the past two decades, macrophages have been recognized as the main players in atherogenesis but also in its thrombotic complications. There is a growing interest in immunometabolism and recent studies on metabolism of macrophages have created new therapeutic options to treat atherosclerosis. Targeting recruitment, polarization, cytokine profile extracellular matrix remodeling, cholesterol metabolism, oxidative stress, inflammatory activity and non-coding RNAs of monocyte/macrophage have been proposed as potential therapeutic approaches against atherosclerosis.
Monocytes/macrophages have a crucial role in progression and pathogenesis of atherosclerosis. Therefore, targeting monocyte/macrophage therapy in order to achieve anti-inflammatory effects might be a good option for prevention of atherosclerosis.
动脉粥样硬化是一种慢性炎症性疾病，也是冠心病、外周血管疾病和中风的主要病因。富含脂质的巨噬细胞来源于循环中的单核细胞，并在外动脉粥样硬化形成的第一步形成脂肪条纹。
我们在主要数据库中进行了电子检索，以综述基于单核细胞/巨噬细胞靶向治疗影响动脉粥样硬化炎症成分的新治疗机会。
在过去的二十年中，巨噬细胞已被认为是动脉粥样硬化形成及其血栓并发症的主要参与者。免疫代谢的兴趣日益浓厚，最近对巨噬细胞代谢的研究为治疗动脉粥样硬化创造了新的治疗选择。针对单核细胞/巨噬细胞的募集、极化、细胞因子谱、细胞外基质重塑、胆固醇代谢、氧化应激、炎症活性和非编码 RNA 的治疗方法已被提出作为治疗动脉粥样硬化的潜在方法。
单核细胞/巨噬细胞在动脉粥样硬化的进展和发病机制中起着至关重要的作用。因此，针对单核细胞/巨噬细胞的治疗方法以实现抗炎作用可能是预防动脉粥样硬化的一个不错的选择。
