肾移植受者体内铝的蓄积及其免疫抑制作用。
Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants.
作者信息
Nordal K P, Dahl E, Albrechtsen D, Halse J, Leivestad T, Tretli S, Flatmark A
机构信息
Department of Medicine, Rikshospitalet, Oslo, Norway.
出版信息
BMJ. 1988 Dec 17;297(6663):1581-2. doi: 10.1136/bmj.297.6663.1581.
Aluminium that has accumulated in the body is thought to have a generalised cytotoxic effect. A prospective study of aluminium accumulation in bone-that is, subclinical aluminium toxicity--was carried out in 94 recipients of kidney allografts, who were followed up for three years. Subclinical aluminium toxicity was found in 66 patients. A significantly smaller proportion of patients with aluminium accumulation experienced a rejection episode: 30 (58%) nu 12 (86%) who received grafts from cadavers and 4 (29%) nu 10 (71%) who received grafts from living donors. On multivariate analysis only the source of the kidney and aluminium accumulation were found to influence the rejection rate. These findings suggest that aluminium accumulation has an immunosuppressive effect.
体内蓄积的铝被认为具有全身性细胞毒性作用。对94例同种异体肾移植受者进行了一项关于骨中铝蓄积（即亚临床铝中毒）的前瞻性研究，随访三年。66例患者发现有亚临床铝中毒。铝蓄积患者发生排斥反应的比例显著较低：接受尸体供肾移植的患者中，30例（58%）对12例（86%）；接受活体供肾移植的患者中，4例（29%）对10例（71%）。多因素分析发现，只有肾脏来源和铝蓄积会影响排斥率。这些发现表明铝蓄积具有免疫抑制作用。
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