Department of Paediatric Cardiology and Rheumatology, Medical University of Lodz, Łódz, Poland.
BMC Musculoskelet Disord. 2019 Aug 31;20(1):392. doi: 10.1186/s12891-019-2776-9.
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic autoinflammatory bone disease that mostly affects children and adolescents. It is a diagnosis of exclusions since no clinical signs and symptoms are pathognomonic. Radiological tests are often essential, but bone biopsy may be needed in unclear cases.
A 9-year-old Caucasian girl with a history of bone pain. The data from the history and results of laboratory tests suggested osteomyelitis, but no adequate response to the treatment was observed. A number of imaging tests did not confirm the diagnosis, therefore a bone biopsy was necessary.
Differential diagnosis of CRMO is challenging and it is based on exclusions. Since it might be misdiagnosed or mistreated, bone biopsy should be considered in patients reporting bone pain who are unresponsive to treatment.
慢性复发性多灶性骨髓炎（CRMO）是一种罕见的特发性自身炎症性骨病，主要影响儿童和青少年。由于没有具有特征性的临床症状和体征，因此这是一种排他性诊断。放射学检查通常很重要，但在不明确的情况下可能需要进行骨活检。
一名 9 岁白人女孩，有骨痛病史。病史和实验室检查结果提示骨髓炎，但治疗后未见明显好转。多项影像学检查均未能确诊，因此需要进行骨活检。
CRMO 的鉴别诊断具有挑战性，需要排除其他疾病。由于可能会误诊或治疗不当，对于报告骨痛且对治疗无反应的患者，应考虑进行骨活检。
