Withdrawal: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: Concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6).
作者信息
Geetha Nishamol, Mihaly Judit, Stockenhuber Alexander, Blasi Francesco, Uhrin Pavel, Binder Bernd R, Freissmuth Michael, Breuss Johannes M
出版信息
J Biol Chem. 2019 Aug 30;294(35):13201. doi: 10.1074/jbc.W119.010444.
Abstract
摘要
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Withdrawal: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: Concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6).撤药：丝裂原活化蛋白激酶/细胞外信号调节激酶（ERK）级联反应中的信号整合与巧合检测：受体酪氨酸激酶和低密度脂蛋白受体相关蛋白1（LRP-1）的同时激活通过双重特异性磷酸酶（DUSP1和-6）的下调导致ERK持续磷酸化。
J Biol Chem. 2019 Aug 30;294(35):13201. doi: 10.1074/jbc.W119.010444.
2
Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6).丝裂原活化蛋白激酶/细胞外信号调节激酶（ERK）级联中的信号整合和偶联检测：受体酪氨酸激酶和 LRP-1 的同时激活通过下调双特异性磷酸酶（DUSP1 和 -6）导致 ERK 磷酸化的持续。
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Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in differentiating P19 cells.在分化的P19细胞中，细胞外信号调节激酶（ERK）和c-Jun氨基末端激酶（JNK）丝裂原活化蛋白激酶（MAPK）通过ERK依赖性和非ERK依赖性诱导丝裂原活化蛋白激酶磷酸酶（MKP）-3和MKP-1进行特定区室调节。
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