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1
Withdrawal: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: Concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6).撤药：丝裂原活化蛋白激酶/细胞外信号调节激酶（ERK）级联反应中的信号整合与巧合检测：受体酪氨酸激酶和低密度脂蛋白受体相关蛋白1（LRP-1）的同时激活通过双重特异性磷酸酶（DUSP1和-6）的下调导致ERK持续磷酸化。
J Biol Chem. 2019 Aug 30;294(35):13201. doi: 10.1074/jbc.W119.010444.
2
Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6).丝裂原活化蛋白激酶/细胞外信号调节激酶（ERK）级联中的信号整合和偶联检测：受体酪氨酸激酶和 LRP-1 的同时激活通过下调双特异性磷酸酶（DUSP1 和 -6）导致 ERK 磷酸化的持续。
J Biol Chem. 2011 Jul 22;286(29):25663-74. doi: 10.1074/jbc.M111.221903. Epub 2011 May 24.
3
Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in differentiating P19 cells.在分化的P19细胞中，细胞外信号调节激酶（ERK）和c-Jun氨基末端激酶（JNK）丝裂原活化蛋白激酶（MAPK）通过ERK依赖性和非ERK依赖性诱导丝裂原活化蛋白激酶磷酸酶（MKP）-3和MKP-1进行特定区室调节。
Biochem J. 2000 Dec 15;352 Pt 3(Pt 3):701-8.
4
Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulation.巨噬细胞通过磷酸酶下调导致的ERK长期激活在高氧环境中存活。
J Biol Chem. 2005 Jul 15;280(28):26295-302. doi: 10.1074/jbc.M500185200. Epub 2005 May 18.
5
Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway.双特异性磷酸酶1缺乏通过丝裂原活化蛋白激酶/细胞外信号调节激酶途径的激活诱导子宫内膜样腺癌进展。
Chin Med J (Engl). 2016 May 20;129(10):1154-60. doi: 10.4103/0366-6999.181954.
6
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.细胞外调节激酶（ERK）1和ERK2是双特异性蛋白酪氨酸磷酸酶VHR的真正底物。在下调ERK途径中具有新作用。
J Biol Chem. 1999 May 7;274(19):13271-80. doi: 10.1074/jbc.274.19.13271.
7
Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line.丝裂原活化蛋白激酶/细胞外信号调节激酶级联在促性腺激素释放激素诱导的人卵巢癌细胞系生长抑制中的作用
Cancer Res. 1999 Oct 15;59(20):5133-42.
8
Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy.细胞外信号调节激酶通路的持续激活可保护细胞免受卟啉介导的光动力疗法的影响。
Cancer Res. 2002 Oct 1;62(19):5528-35.
9
Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation.有丝分裂原依赖性DUSP1调控在3T3-L1脂肪细胞早期分化过程中对ERK和p38信号通路的调节。
J Cell Physiol. 2016 Jul;231(7):1562-74. doi: 10.1002/jcp.25248. Epub 2015 Nov 30.
10
GP78 Cooperates with Dual-Specificity Phosphatase 1 To Stimulate Epidermal Growth Factor Receptor-Mediated Extracellular Signal-Regulated Kinase Signaling.GP78 通过与双特异性磷酸酶 1 相互作用来刺激表皮生长因子受体介导的细胞外信号调节激酶信号通路。
Mol Cell Biol. 2019 May 14;39(11). doi: 10.1128/MCB.00485-18. Print 2019 Jun 1.

Withdrawal: Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: Concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down-regulation of dual specificity phosphatases (DUSP1 and -6).

作者信息

Geetha Nishamol, Mihaly Judit, Stockenhuber Alexander, Blasi Francesco, Uhrin Pavel, Binder Bernd R, Freissmuth Michael, Breuss Johannes M

出版信息

J Biol Chem. 2019 Aug 30;294(35):13201. doi: 10.1074/jbc.W119.010444.

DOI:10.1074/jbc.W119.010444
PMID:31471383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6721935/
Abstract
摘要