Bieri F, Stäubli W, Waechter F, Muakkassah-Kelly S, Bentley P
Central Toxicology Unit, Ciba-Geigy Limited, Basel, Switzerland.
Cell Biol Int Rep. 1988 Dec;12(12):1077-87. doi: 10.1016/0309-1651(88)90032-x.
The effects of the peroxisome proliferator nafenopin upon primary cultures of marmoset hepatocytes have been investigated and compared to those on cultured rat hepatocytes. Nafenopin did not induce peroxisomal beta-oxidation or peroxisome proliferation but did induce replicative DNA synthesis. These findings demonstrate that peroxisome proliferation and mitogenicity are two independent properties of nafenopin and question the widely held view that primates are generally insensitive to the effects of peroxisome proliferators.
已对过氧化物酶体增殖剂萘酚平对狨猴肝细胞原代培养物的作用进行了研究，并与对培养大鼠肝细胞的作用进行了比较。萘酚平未诱导过氧化物酶体β-氧化或过氧化物酶体增殖，但诱导了DNA复制性合成。这些发现表明，过氧化物酶体增殖和促有丝分裂性是萘酚平的两个独立特性，并对灵长类动物通常对过氧化物酶体增殖剂的作用不敏感这一广泛持有的观点提出了质疑。
