Department of Surgery, Duke University, Durham, NC, USA.
Duke University Medical Center, Durham, NC, USA.
Ann Surg Oncol. 2020 Jan;27(1):35-42. doi: 10.1245/s10434-019-07760-7. Epub 2019 Aug 30.
In-transit melanoma represents a distinct disease pattern in which melanoma recurs as dermal or subcutaneous nodules between the primary melanoma site and the draining regional lymph node basin. The disease pattern is often not amenable to complete surgical resection. Since the 1950s, regional therapies have been explored for the treatment of this disease entity, with the goal of maximizing delivery of the therapeutic agent to the tumor while minimizing systemic toxicity. We reviewed landmark studies describing and evaluating regional chemotherapy and intralesional therapies for patients with in-transit melanoma metastases.
在途性黑色素瘤是一种独特的疾病模式，其特征是黑色素瘤在原发黑色素瘤部位和引流区域淋巴结之间的皮肤或皮下结节中复发。这种疾病模式通常不能完全通过手术切除来治疗。自 20 世纪 50 年代以来，人们一直在探索区域治疗方法来治疗这种疾病实体，其目标是在最大程度地将治疗剂输送到肿瘤的同时，最小化全身性毒性。我们回顾了描述和评估局部化疗和肿瘤内治疗在治疗在途性黑色素瘤转移患者的里程碑式研究。
