K+-loss of frog nerves during electric stimulation.

Proximal section of nervus ischiadicus of frog was directly stimulated, and distal section of the same length was stimulated indirectly. Indirect stimulation resulted in a 2 per cent loss of K+ content, direct stimulation caused a loss of 31 per cent of the K+ content. Indirect stimulation does not cause a significant K+ efflux; direct stimulation results in a significant decrease in K+ content even at a probability level of p=0.001. A correlation was found between the changes in the K+ content of frog nerve and the intensity of the applied electric impulses. The decrease of K+ content of frog nerves is in ratio with the logarithm of stimulation voltage.