Locateli João Carlos, Lopes Wendell Arthur, Simões Caroline Ferraz, de Oliveira Gustavo Henrique, Oltramari Karine, Bim Ricardo Henrique, de Souza Mendes Victor Hugo, Remor Jane Maria, Lopera Carlos Andrés, Nardo Junior Nelson
Department of Physical Education, State University of Maringá, Maringá, Brazil.
Department of Physical Education, State University of Maringa, Av. Colombo, 5.790, Campus Universitário, Maringa,Paraná 87020-90, Brazil, Phone: +55(44)998794895, E-mail:
J Pediatr Endocrinol Metab. 2019 Oct 25;32(10):1163-1170. doi: 10.1515/jpem-2019-0037.
Background The aim of the present study was to investigate the correlation between the triglyceride/glucose index (TyG index) and homeostasis model assessment of insulin resistance (HOMA-IR). Additionally, we compared the ability of the TyG index and triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) index and the combination of these two indices (TyG index plus TG/HDL-c) to predict insulin resistance (IR) in South American overweight and obese children and adolescents. Methods A cross-sectional study was carried out in 345 overweight adolescents aged 10-18 years, from both the sexes. The TyG index was calculated as Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL])/2, while the TG/HDL-c index was calculated by the division of TG (mg/dL) by HDL-c (mg/dL). HOMA-IR was calculated with the formula: fasting insulin (FI) (U/mL) × fasting glucose (mmol/L)/22.5. The cut-off point used to determine the presence of IR was HOMA-IR ≥ 3.16. Results The TyG index showed a positive correlation with HOMA-IR. The area under the receiver operating characteristic (ROC) curve of the TyG index was 0.74, indicating good sensitivity (75.7%) and specificity (67.4%). Furthermore, the TyG index cut-off point of >4.44 was established for IR prediction in this population. Conclusions The TyG index is a simple and cost-effective surrogate marker of IR in South American overweight children and adolescents. Moreover, due to its good accessibility, it can be used in large epidemiological studies.
背景 本研究旨在探讨甘油三酯/葡萄糖指数（TyG指数）与胰岛素抵抗稳态模型评估（HOMA-IR）之间的相关性。此外，我们比较了TyG指数、甘油三酯/高密度脂蛋白胆固醇（TG/HDL-c）指数以及这两个指数的组合（TyG指数加TG/HDL-c）预测南美超重和肥胖儿童及青少年胰岛素抵抗（IR）的能力。方法 对345名年龄在10至18岁的超重青少年进行了一项横断面研究，涵盖了男女两性。TyG指数计算公式为Ln（空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]）/2，而TG/HDL-c指数通过TG（mg/dL）除以HDL-c（mg/dL）计算得出。HOMA-IR采用公式计算：空腹胰岛素（FI）（U/mL）×空腹血糖（mmol/L）/22.5。用于确定IR存在的截断点为HOMA-IR≥3.16。结果 TyG指数与HOMA-IR呈正相关。TyG指数的受试者工作特征（ROC）曲线下面积为0.74，表明具有良好的敏感性（75.7%）和特异性（67.4%）。此外，在该人群中确定了用于IR预测的TyG指数截断点>4.44。结论 TyG指数是南美超重儿童及青少年IR的一种简单且经济有效的替代标志物。此外，由于其良好的可及性，可用于大型流行病学研究。
