中性粒细胞与淋巴细胞比值对脑胶质瘤预后的影响：系统评价和荟萃分析。
Prognostic impact of neutrophil-to-lymphocyte ratio in gliomas: a systematic review and meta-analysis.
机构信息
Department of Oncology, Hebei General Hospital, Shijiazhuang, 050051, Hebei, China.
出版信息
World J Surg Oncol. 2019 Aug 31;17(1):152. doi: 10.1186/s12957-019-1686-5.
BACKGROUND
In some malignant tumors, a high neutrophil-to-lymphocyte ratio (NLR) is connected with unfavorable prognosis. Nevertheless, the prognostic value of the NLR in gliomas remains disputed. The clinical significance of the NLR in gliomas was investigated in our study.
METHODS
The databases, PubMed, Embase, and the Cochrane Library, were searched using words like "glioma," "glioblastoma," "neutrophil-to-lymphocyte ratio," and others through May 2019. We evaluated the significance of NLR on overall survival (OS) of patients with gliomas in our study.
RESULTS
Finally, 16 cohorts with 2275 patients were analyzed. The pooled analysis revealed that an elevated NLR was connected with unfavorable OS (hazards ratio (HR): 1.43, 95% confidence interval (CI): 1.27-1.62) outcomes of patients with gliomas.
CONCLUSION
A high NLR can be considered a high-risk prognostic factor in gliomas, and more adjuvant chemotherapy should be recommended for high-risk patients.
背景
在一些恶性肿瘤中，高中性粒细胞与淋巴细胞比值（NLR）与不良预后相关。然而，NLR 在神经胶质瘤中的预后价值仍存在争议。本研究旨在探讨 NLR 在神经胶质瘤中的临床意义。
方法
通过使用“glioma”、“glioblastoma”、“neutrophil-to-lymphocyte ratio”等词，在 PubMed、Embase 和 Cochrane Library 数据库中检索截至 2019 年 5 月的相关文献。我们评估了 NLR 对神经胶质瘤患者总生存（OS）的意义。
结果
最终分析了 16 项包含 2275 例患者的队列研究。荟萃分析显示，升高的 NLR 与神经胶质瘤患者的不良 OS（风险比（HR）：1.43，95%置信区间（CI）：1.27-1.62）结局相关。
结论
高 NLR 可被视为神经胶质瘤的高危预后因素，应建议高危患者进行更多辅助化疗。
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