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C-醋酸盐和F-氟脱氧葡萄糖PET/计算机断层扫描在肝细胞癌钇微球放射性栓塞治疗中的重要价值

Significant Value of C-Acetate and F-Fluorodeoxyglucose PET/Computed Tomography on Y Microsphere Radioembolization for Hepatocellular Carcinoma.

作者信息

Ho Chi Lai, Chen Sirong, Cheung Shing Kee, Leung Thomas Wai Tong

机构信息

Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China.

Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China; Medical Physics & Research Department, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China.

出版信息

PET Clin. 2019 Oct;14(4):459-467. doi: 10.1016/j.cpet.2019.06.005. Epub 2019 Jul 31.

DOI:10.1016/j.cpet.2019.06.005
PMID:31472743
Abstract

Pretreatment dual-tracer (F-fluorodeoxyglucose and C-acetate) PET/computed tomography (CT) has potential to predict treatment response for Y microsphere radioembolization (RE) in patients with inoperable hepatocellular carcinoma (HCC). Patients with C-acetate-avid HCC have a better response to Y microsphere RE, and possibly better survival. Pretreatment dual-tracer PET/CT has a significant theranostic value on Y microsphere RE in determining target tumor dose for HCCs with different cellular differentiation, metabolic tumor volume, and functioning liver volume, and can be used to prescribe individual injected activity of Y microspheres.

摘要

治疗前双示踪剂（F-氟脱氧葡萄糖和C-乙酸盐）正电子发射断层显像/计算机断层扫描（PET/CT）有潜力预测不可切除肝细胞癌（HCC）患者接受钇90微球放射性栓塞（RE）治疗的反应。C-乙酸盐摄取阳性的HCC患者对钇90微球RE反应更好，且可能有更好的生存期。治疗前双示踪剂PET/CT在确定不同细胞分化、代谢肿瘤体积和功能性肝体积的HCC的靶肿瘤剂量方面，对钇90微球RE具有显著的诊疗价值，可用于个体化确定钇90微球的注射活度。

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