Department of Chemistry, Istanbul Technical University, Maslak, 34469, Istanbul, Turkey.
Department of Chemistry, Istanbul Technical University, Maslak, 34469, Istanbul, Turkey.
Carbohydr Polym. 2019 Nov 15;224:115165. doi: 10.1016/j.carbpol.2019.115165. Epub 2019 Aug 5.
This study aims to modify alginate with sodium dodecyl sulfate (SDS) to reduce the release of oral protein in the acidic stomach environment and transport it to the colon medium. Bovine serum albumin (BSA), which was chosen as a model protein, was loaded into surfactant modified calcium alginate beads (SDS/Ca-Alg). The encapsulation efficiency of BSA in SDS/Ca-Alg beads was found significantly higher (96.3%) compared to that of beads without SDS. The most remarkable result is that protein release from the modified gel in the stomach environment was significantly reduced compared to protein release from the plain alginate gel. At the same time, the release time of the whole drug in the intestinal environment was significantly prolonged. The SDS-modified alginate beads are proposed as suitable carriers for the passage of orally taken protein-type drugs into the colon medium by preventing their degradation in acidic gastric fluid.
本研究旨在通过用十二烷基硫酸钠（SDS）对海藻酸钠进行改性，以减少在酸性胃部环境中口服蛋白质的释放，并将其输送到结肠介质中。牛血清白蛋白（BSA）被选为模型蛋白，将其装载到表面活性剂改性的海藻酸钙珠（SDS/Ca-Alg）中。与不含 SDS 的珠子相比，BSA 在 SDS/Ca-Alg 珠中的包封效率显著提高（96.3%）。最显著的结果是，与 plain alginate gel 相比，改性凝胶在胃部环境中释放蛋白质的量明显减少。同时，在肠道环境中整个药物的释放时间明显延长。SDS 改性的海藻酸钠珠被提议为口服蛋白类药物通过酸性胃液进入结肠介质的合适载体，以防止其在酸性胃液中降解。
