Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
Center for Neurodegenerative Sciences, Van Andel Research Institute, 333 Bostwick Avenue NE, Grand Rapids, MI 49503, USA.
Trends Endocrinol Metab. 2019 Oct;30(10):687-689. doi: 10.1016/j.tem.2019.08.001. Epub 2019 Aug 28.
A new mouse model of Parkinson's disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits in wild-type mice. These findings support the idea that the gut could be a starting point for PD.
一种新的帕金森病（PD）小鼠模型显示，α-突触核蛋白病理通过迷走神经从肠道传播到大脑（Kim 等人，神经元，2019）。该病理学与野生型小鼠的运动和非运动行为缺陷有关。这些发现支持了肠道可能是 PD 起始点的观点。
